Scientific discovery dossier · Experimental discoveries
Photo-controlled calcium storm — Ca²⁺ overload in tumor cells
Photo-Controlled Calcium Overload from Endogenous Sources for Tumor Therapy
- Record type
- Preclinical scientific discovery (not a clinical trial)
- Publication
- Peer-reviewed
- DOI
- 10.1002/anie.202317578
- Editorial update
- 2026-10-29
Not a treatment recommendation. Experimental or ongoing research does not by itself replace standard care.
- Scope / models
- Multiple / solid tumors — Preklinik: tümör hücre hatları ve tümör implantlı fare modelleri
- Molecular mechanism
- Extracellular Ca²⁺ influx (TRPA1/ROS) plus ER Ca²⁺ release (NO → ryanodine receptor) cause cytoplasmic Ca²⁺ overload targeting mitochondrial failure. No exogenous Ca²⁺ source required.
- Experimental models
- Tumor cell cultures; injectable HA-coated mesoporous silica nanomodulator; tumor regression after NIR irradiation reported in tumor-bearing mice.
- Translational distance
- Not a human clinical trial or approved therapy. Selectivity, systemic toxicity, and translation into surgical oncology practice are unproven.
For patients
What is being studied? In the lab, a light-triggered method tried to kill cancer cells by flooding them with calcium. This is not a treatment tested in people.
Why promising? Using light to open endogenous Ca²⁺ channels and create an intracellular ‘calcium storm’ showed preclinical tumor-inhibition signals (Angew. Chem. Int. Ed. 2024; Ewha/China collaboration).
What is not proven? Human clinical efficacy, safe dosing, tissue selectivity, long-term toxicity, or superiority to standard care. This is not a treatment option.
Is this standard care today? No — this is a laboratory/scientific discovery dossier, not a treatment option.
For clinicians
DOI 10.1002/anie.202317578. Primary: photo-controlled endogenous Ca²⁺ overload. Press language uses ‘calcium storm’; no clinical claim. Physician: preclinical discovery card.
Limitations: Tek merkezli preklinik nanoteknoloji; insan verisi yok; cerrahi onkoloji endikasyonu yok.