Scientific discovery dossier · Experimental discoveries
TRP channels, calcium homeostasis, and metastasis — discovery dossier
Composite discovery dossier (not a single clinical trial): TRPM7 / TRPV4 experimental metastasis literature + review
- Record type
- Preclinical scientific discovery (not a clinical trial)
- Publication
- Peer-reviewed
- DOI
- 10.1016/j.biopha.2022.114074
- Editorial update
- 2026-10-29
Not a treatment recommendation. Experimental or ongoing research does not by itself replace standard care.
- Scope / models
- Multiple / solid tumors — Kanser türüne özgü modeller: meme (TRPM7, TRPV4), akciğer (TRPM7), endometriyum (TRPV4); GI’ye otomatik genellenmez
- Molecular mechanism
- TRP channels alter intracellular Ca²⁺ affecting migration, adhesion, and cytoskeletal pathways. Examples: TRPM7 (breast xenograft metastasis); TRPV4–AKT–E-cadherin (breast); TRPV4–RhoA/ROCK1 (endometrial).
- Experimental models
- Cell migration/invasion; xenograft/experimental metastasis mouse models; clinical cohort correlations (correlation ≠ causation).
- Translational distance
- A composite of multiple papers — not one clinical trial. Does not claim organ-specific metastasis mechanisms are fully solved.
- Research biomarker
- TRPM7 / TRPV4 (örnek kanallar)
For patients
What is being studied? Lab studies in different cancer types explore whether calcium channels may affect spread. This is not a single clinical drug trial.
Why promising? Links between Ca²⁺-permeable TRP channels and metastatic phenotypes generate selective channel-target hypotheses.
What is not proven? Human clinical benefit; a single TRP mechanism for all metastases; approved TRP-inhibitor therapy in GI cancers.
Is this standard care today? No — this is a laboratory/scientific discovery dossier, not a treatment option.
For clinicians
Review DOI 10.1016/j.biopha.2022.114074 + example primaries: TRPM7 10.1158/0008-5472.CAN-11-3863; TRPV4 10.1038/oncsis.2017.39; 10.1038/s41419-020-03181-7. Do not present as one NCT.
Limitations: Heterojen kanser türleri; derleme + seçilmiş primerler; GI cerrahi endikasyon yok.