Scientific discovery dossierExperimental discoveries
Pancreas · Multiple / solid tumors
Discovery dossier: RAS(ON) preclinical concept underpinning clinical programs — not a care standard.
Experimental models: Cell lines and animal models (clinical translation is on separate cards).
Translational distance: Human clinical benefit cannot be inferred here. Clinical: RMC-6236-001, RASolute 302, elironrasib/daraxonrasib.
Not a clinical trial or treatment option.
Scientific discovery dossierExperimental discoveriesDOI 10.1002/anie.202317578
Multiple / solid tumors
Discovery dossier: light-triggered endogenous Ca²⁺ storm. No human clinical efficacy evidence.
Experimental models: Tumor cell cultures; injectable HA-coated mesoporous silica nanomodulator; tumor regression after NIR irradiation reported in tumor-bearing mice.
Translational distance: Not a human clinical trial or approved therapy. Selectivity, systemic toxicity, and translation into surgical oncology practice are unproven.
Not a clinical trial or treatment option.
Scientific discovery dossierExperimental discoveriesDOI 10.1016/j.bbamcr.2014.02.012
Pancreas
Discovery dossier: STIM1/ORAI1 SOCE contributes to apoptotic resistance in PDAC cells — not a clinical test.
Experimental models: Pancreatic adenocarcinoma cell lines / in vitro SOCE measurements.
Translational distance: Not a validated clinical predictive test or approved drug target. Does not change surgical/adjuvant decisions.
Not a clinical trial or treatment option.
Scientific discovery dossierExperimental discoveriesDOI 10.21037/tcr-2024-2563
Multiple / solid tumors
Discovery dossier: SOCE_Score studied in neuroblastoma datasets — not a clinic-validated predictive test.
Experimental models: Multiple neuroblastoma RNA-seq datasets; claimed validation across cohorts; CMap drug-repurposing hypothesis.
Translational distance: Not a GI surgical oncology standard. Must not be presented as an approved predictive test. Needs medical review.
Not a clinical trial or treatment option.
Scientific discovery dossierExperimental discoveriesDOI 10.1002/emmm.201302989
Multiple / solid tumors
Discovery dossier: SOCE is critical for CD8+ antitumor immunity — not a human treatment protocol.
Experimental models: Conditional knockout mice; in vivo tumor-immunity experiments.
Translational distance: Generates immunotherapy-combination hypotheses; no clinical SOCE-inhibitor indication.
Not a clinical trial or treatment option.
Scientific discovery dossierExperimental discoveriesDOI 10.1016/j.biopha.2022.114074
Multiple / solid tumors
Discovery dossier (not one NCT): TRP–Ca²⁺–metastasis links are cancer-type specific; no claim that organ metastasis is ‘solved’.
Experimental models: Cell migration/invasion; xenograft/experimental metastasis mouse models; clinical cohort correlations (correlation ≠ causation).
Translational distance: A composite of multiple papers — not one clinical trial. Does not claim organ-specific metastasis mechanisms are fully solved.
Not a clinical trial or treatment option.