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Research areaEmerging treatment technologiesPriority: very high

Personalized mRNA cancer vaccines

Melanoma · Pancreas · Multiple / solid tumors

Research area: personalized mRNA vaccines. KEYNOTE-942, V940 phase III, and pancreas vaccine cards are listed separately underneath.

Evidence level: Randomized phase IIb results in melanoma plus phase III confirmation trials; early clinical in pancreas.

Not a single trial · 3 linked records

Research areaEmerging treatment technologiesPriority: very high

PROTACs — targeted protein degradation

Pancreas · Multiple / solid tumors

Research area: protein degradation. Setidegrasib (KRAS G12D) clinical card underneath; separate from classic inhibitor cards.

Evidence level: 2026 phase I clinical activity signal for KRAS G12D degrader setidegrasib (ASP3082) in NEJM; not standard care.

Not a single trial · 1 linked records

Research areaEmerging treatment technologiesPriority: very high

Bispecific antibody–drug conjugates (BsADCs)

Gastric / esophageal · Biliary tract · Multiple / solid tumors

Research area: BsADCs. BL-B01D1 esophagus/biliary phase III cards underneath; zanidatamab is not an ADC.

Evidence level: Some molecules in phase III / regional programs; izalontamab brengitecan (BL-B01D1) as an example. Not all BsADCs are equivalent.

Not a single trial · 2 linked records

Research areaEmerging treatment technologiesPriority: high

Armored CAR-T — solid tumors

Multiple / solid tumors

Research area: armored CAR-T. Early-phase ARMADA example underneath; do not conflate with hematologic CAR-T.

Evidence level: Mostly early clinical (phase I) in solid tumors. Hematologic CAR-T success does not automatically transfer.

Not a single trial · 1 linked records