CDH1 (Hereditary Diffuse Gastric Cancer)

• Who is offered evaluation?+−

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  Multiple diffuse gastric cancers in a family, young-onset diffuse gastric cancer, CDH1-compatible lobular breast history, or a known family mutation are common triggers.

• Surveillance vs surgery+−

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  Endoscopic surveillance has limits in diffuse disease. Risk-reducing total gastrectomy is individualized — not a single forced date for every carrier.

• Breast risk and relatives+−

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  Lobular breast risk may need intensified screening plans. Cascade testing for relatives runs through genetic counseling.

• Important+−

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  This page is for education. It is not medical advice and does not replace a visit with your physician.

More chapters in this hub

• Hereditary Cancer Overview

  When hereditary risk is considered and how sequencing works

• Lynch Syndrome

  MMR/MSI, colorectal risk, and family screening

• BRCA and Familial Breast Risk

  Who is offered testing; surgery and surveillance frame

• FAP

  Polyposis, APC, and surgical timing

• Li-Fraumeni Syndrome

  TP53 and multi-cancer spectrum

• Peutz–Jeghers Syndrome

  Hamartomatous polyps and surveillance

• Genetic Counseling

  Consent, results, and talking with relatives

• Molecular Testing in Cancer

  Organ-specific biomarkers that often open this conversation