Li-Fraumeni Syndrome

• When to raise the question+−

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  Very young-onset breast cancer or sarcoma, multiple primaries, or first-degree relatives with LFS-spectrum cancers are reasons to ask — not automatic diagnoses.

• Imaging and treatment+−

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  When feasible, teams may prefer lower-radiation strategies; choices are shared with oncology and genetics. Emergency surgery is not delayed solely for panels.

• Family plan+−

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  Pathogenic TP53 findings open cascade testing and intensified surveillance pathways under counseling. This page does not replace those protocols.

• Important+−

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  This page is for education. It is not medical advice and does not replace a visit with your physician.

More chapters in this hub

• Hereditary Cancer Overview

  When hereditary risk is considered and how sequencing works

• Lynch Syndrome

  MMR/MSI, colorectal risk, and family screening

• BRCA and Familial Breast Risk

  Who is offered testing; surgery and surveillance frame

• FAP

  Polyposis, APC, and surgical timing

• CDH1

  Hereditary diffuse gastric cancer risk

• Peutz–Jeghers Syndrome

  Hamartomatous polyps and surveillance

• Genetic Counseling

  Consent, results, and talking with relatives

• Molecular Testing in Cancer

  Organ-specific biomarkers that often open this conversation